Gel Electrophoresis Reagents and Buffers
Cayman Chemical KB-0742hydrochlorIde 25mg
A Cdk9 inhibitor (IC50 = 6 nM); selective for Cdk9 over Cdk1-8 (IC50s = 397->10,000 nM) and Cdk12-19 (IC50s = 372->10,000 nM); induces cell cycle arrest at the G1 phase and apoptosis in BT-20, BT-549, MDA-MB-231, MT-3, and Hs 578T TNBC cells from 0.64-7.73 µM; reduces tumor volume in the MYC-amplified CTG-0437 PDX mouse model of TNBC at 60 mg/kg
R Peptide LLC Tau Protein Ladder, of all 6 isoforms, 50 uL
Tau is a family of major neuronal microtubule associated proteins that are found in the neurofibrillary tangles (NFT) in Alzheimer's disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells. The Tau proteins are derived from alternative mRNA splice variants that originate from a single gene and result in mature proteins that vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa).
Zymo Research Corporation ChIP DNA Binding Buffer, 50 ml
The ChIP DNA Binding Buffer is for use with the Zymo-Spin™ ChIP Kit as well as the Genomic DNA Clean & Concentrator™.
MOLTOX Molecular Toxicology Inc Phosphate Peptone Buffer (PPB), pH 7.0 +/- 0.2. 100 mL/bottle. Store at room temperature.
This item has a minimum order quantity of 96 per supplier requirements. MOLTOX manufactures a wide variety of buffers for your laboratory needs. All MOLTOX reagents are accompanied by a GLP-compliant Formulation and Quality Control statement.
MOLECULAR DEPOT LLC Tacrolimus Buffer - 25 mL
Tacrolimus Release Buffer is an extraction solution for the release of tacrolimus from its protein-bound form This product has been used as a tool for the research of detection systems for Tacrolimus Store at 2-8C For in vitro research use only
ABclonal Technology GPX2 Rabbit pAb
The protein encoded by this gene is a member of the glutathione peroxidase family, which reduces organic hydroperoxides and hydrogen peroxide (H2O2) using glutathione, protecting cells from oxidative damage. This isozyme is mainly expressed in the gastrointestinal tract and liver (in humans), localized in the cytoplasm, and prefers hydrogen peroxide as its substrate. Overexpression is linked to increased differentiation and proliferation in colorectal cancer. It is also a selenoprotein, with selenocysteine (Sec) at its active site, encoded by the UGA codon. The 3 UTR of selenoprotein mRNAs contains a stem-loop structure called the SECIS element, essential for interpreting UGA as Sec, not a stop codon. Alternative splicing variants of this gene have been identified.
ABclonal Technology NAB1 Rabbit pAb
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within endochondral ossification, nervous system development, and regulation of epidermis development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus.
Revvity Health Sciences Inc RNA Pico Assay Reagent Ladder (bulk)
RNA Pico Assay Reagent Ladder (bulk)
Cell Signaling Technology RBC Lysis Buffer (10X) #46232, Concentrated Ammonium Chloride-Based Buffer
RBC Lysis Buffer (10X) 100 ml
Ubpbio 6xHis-UbE2F (NCE2) Human, 100 µg
UbE2F is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for conjugation of Nedd8 to protein substrates. Neddylation is initiated by activating Nedd8 by the Nedd8 activating enzyme APPBP1/UBA3. Cullin is a well-known substrate for Neddylation. When NEDD8 is covalently bonded to the CRL, it stimulates its E3 Ub ligase activity. A new approach to cancer therapy involves hindering the Nedd8 conjugation pathway through inhibition of the NAE1/UBA3 enzyme.
ABclonal Technology DMT1/SLC11A2 Rabbit pAb
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology COL11A1 Rabbit pAb
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene.
ABclonal Technology KCNMB2 Rabbit pAb
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described.